منابع مشابه
Hedgehog, meet Patched
H edgehog protein and its receptor are made for each other, but even this perfect couple needs a little help to get together. Li et al. (1) reveal that a proteoglycan plays cupid for the molecules and sparks signal transduction through the Hedgehog pathway, a mechanism exploited by a type of childhood cancer. During development, Hedgehog proteins are sculptors, helping to mold the embryo’s limb...
متن کاملHedgehog, Patched and Dispatched near the basement.
C ell signaling is arguably the most important characteristic of multicellular organisms. Without cell signaling, the different cells in the body of a plant or animal could not communicate with each other, and they could not coordinate their actions. Such coordination is essential: first, to build a complex body composed of thousands or millions of cells and second, for the correct performance ...
متن کاملHedgehog Signalling: Pulling Apart Patched and Smoothened
Two integral membrane proteins, Patched and Smoothened, were for a long time thought to comprise a preformed receptor complex for secreted Hedgehog signalling proteins. Recent analyses of the subcellular distribution of these proteins argue strongly against this simple model.
متن کاملDevelopmental pathways: Sonic hedgehog-Patched-GLI.
Developmental pathways are networks of genes that act coordinately to establish the body plan. Disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Environmental exposures can be associated with poor pregnancy outcomes, including dysmorphic offspring or children with a variety of diseases. An important goal of environment...
متن کاملHedgehog and Patched Review in Neural Development
1989; Nakano et al., 1989) that dictates alternative developmental decisions or inhibits growth unless opposed by Hh activity. For example, in ptc mutant fly embryos, the central pattern elements of the ventral epidermis are Stanford University School of Medicine deleted and replaced with mirror-image duplications of Stanford, California 94305 the segment borders (Nü sslein-Volhard and Wieschau...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2011
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1924if